Congenital Hypertrophy of the Retinal Pigment Epithelium: Following the Bear Tracks
Résumé
Congenital hypertrophy of the retinal pigment epithelium (CHRPE) is a well-recognized benign ocular finding, characterized by flat, pigmented lesions. CHRPE lesions are typically unilateral and solitary but can also present as multiple or bilateral occurrences. They are relatively common, asymptomatic, and usually diagnosed incidentally during routine eye examinations. While generally benign, CHRPE or CHRPE-like lesions may warrant further evaluation to rule out systemic disorders such as familial adenomatous polyposis (FAP) or other differential diagnoses, especially in atypical or multiple lesions.
Références
Shields JA, Shields CL. Tumors and related lesions of the pigmented epithelium. Asia-Pac J Ophthalmol (Phila). 2017;6(2):215-223. doi:10.22608/APO.201705
Shields CL, Mashayekhi A, Ho T, Cater J, Shields JA. Solitary congenital hypertrophy of the retinal pigment epithelium: clinical features and frequency of enlargement in 330 patients. Ophthalmology. 2003;110(10):1968-1976. doi:10.1016/S0161-6420(03)00618-3
Reese AB, Jones IS. Benign melanomas of the retinal pigment epithelium. Am J Ophthalmol. 1956;42(2):207-212. doi:10.1016/0002-9394(56)90922-9
Purcell JJ, Shields JA. Hypertrophy with hyperpigmentation of the retinal pigment epithelium. Arch Ophthalmol. 1975;93(11):1122-1126. doi:10.1001/archopht.1975.01010020840002
Champion R, Daicker BC. Congenital hypertrophy of the pigment epithelium: light microscopic and ultrastructural findings in young children. Retina. 1989;9(1):44-48.
Ireland AC, Rodman J. Congenital hypertrophy of retinal pigment epithelium [Internet]. In: StatPearls. Treasure Island (FL): Stat Pearls Publishing; 2026 [updated 2024 May 15, accessed 2025 April 6]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK576424/
Li CJ, Yaghy A, Shields CL. Pigmented ocular fundus lesions associated with familial adenomatous polyposis. ophthalmic surgery, lasers and imaging retina. Ophthalmic Surg Lasers Imaging Retina. 2020;51(2):124. doi:10.3928/23258160-20200129-10
Hennessy MP, Collins F, Coroneo MT. The distinction between multiple retinal pigment epithelial hamartomata (MRPEH) in familial adenomatous polyposis (FAP) and congenital hypertrophy of the retinal pigment epithelium (CHRPE). Aust N Z J Ophthalmol. 1993;21(4):275-276. doi:10.1111/j.1442-9071.1993.tb00969.x
Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW, et al. ACG Clinical Guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol. 2015;110(2):223-263. doi:10.1038/ajg.2014.435
Deibert B, Ferris L, Sanchez N, Weishaar P. The link between colon cancer and congenital hypertrophy of the retinal pigment epithelium (CHRPE). Am J Ophthalmol Case Rep. 2019;15:100524. doi:10.1016/j.ajoc.2019.100524
Brosens LAA, Wood LD, Offerhaus GJ, Arnold CA, Lam-Himlin D, Giardiello FM, et al. Pathology and genetics of syndromic gastric polyps. Int J Surg Pathol. 2016;24(3):185-199. doi:10.1177/1066896915620013
Khattab A, Monga DK. Turcot syndrome [Internet]. In: StatPearls. Treasure Island (FL): Stat Pearls Publishing; 2026 [updated 2023 June 26, accessed April 7, 2025]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK534782/
Coleman P, Barnard NAS. Congenital hypertrophy of the retinal pigment epithelium: prevalence and ocular features in the optometric population. Ophthalmic Physiol Opt. 2007;27(6):547-555. doi:10.1111/j.1475-1313.2007.00513.x
Nusliha A, Dalpatadu U, Amarasinghe B, Chandrasinghe PC, Deen KI. Congenital hypertrophy of retinal pigment epithelium (CHRPE) in patients with familial adenomatous polyposis (FAP); a polyposis registry experience. BMC Res Notes. 2014;7:734. doi:10.1186/1756-0500-7-734
Meyer CH, Gerding H. Chapter 136 - congenital hypertrophy of the retinal pigment epithelium. In Editors: Ryan SJ, Sadda SR, Hinton DR, Schachat AP, Sadda SR, Willkinson CP, et al., Retina (Fifth Edition). W.B. Saunders; 2013. p. 2209-2213. doi:10.1016/B978-1-4557-0737-9.00136-3.
van der Torren K, Luyten GPM. Progression of papillomacular congenital hypertrophy of the retinal pigment epithelium associated with impaired visual function. Arch Ophthalmol. 1998;116(2):256-257. doi:10.1001/archopht.116.2.256
Shields CL, Pirondini C, Bianciotto C, Harmon SA, Shields JA. Autofluorescence of congenital hypertrophy of the retinal pigment epithelium. Retina. 2007;27(8):1097-100. doi:10.1097/IAE.0b013e318133a174
Shields CL, Materin MA, Walker C, Marr BP, Shields JA. Photoreceptor loss overlying congenital hypertrophy of the retinal pigment epithelium by optical coherence tomography. Ophthalmology. 2006;113(4):661-665. doi:10.1016/j.ophtha.2005.10.057
Touriño R, Rodríguez-Ares MT, López-Valladares MJ, Gómez-Ulla F, Gómez-Torreiro M, Capeans C. Fluorescein angiographic features of the congenital hypertrophy of the retinal pigment epithelium in the familial adenomatous polyposis. Int Ophthalmol. 2005;26(1-2):59-65. doi:10.1007/s10792-006-0007-5
Bellamy JP, Cohen SY. Congenital hypertrophy of the retinal pigment epithelium complicated by choroidal neovascularization. Ophthalmol Retina. 2022;6(6):511. doi:10.1016/j.oret.2022.02.005
Téléchargements
Publié
Comment citer
Numéro
Rubrique
Licence
© Canadian Eye Care Today 2026
Cette œuvre est sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.
