Ocular Fundus Tumours: A Simplified Clinical Classification

Authors

  • Hatem Krema, MD, MSc, FRCS, FICO (Hon.) Ocular Oncology Princess Margaret Cancer Centre/ UHN, Toronto, ON

DOI:

https://doi.org/10.58931/cect.2024.3349

Abstract

The diagnosis of the most common ocular fundus tumours can be achieved according to clinical features including their malignant potential, anatomical location within the eye, and relation to systemic disease, as well as imaging features. The majority of these tumours can be classified into four major categories according to their clinical presentation.

Author Biography

Hatem Krema, MD, MSc, FRCS, FICO (Hon.), Ocular Oncology Princess Margaret Cancer Centre/ UHN, Toronto, ON

Prof. Dr. Hatem Krema is the director of the Ocular Oncology program at Princess Margaret Cancer Centre, University Health Network, University of Toronto, Canada. Dr. Krema had his ocular oncology training in the USA, UK, and Canada. He is interested in translational clinical research in the field of ophthalmic oncology. His focus is on defining better algorithms for radiotherapy of the ocular and adnexal cancers, management of treatment-related complications, introduction of innovative surgical techniques, and the role of molecular genomics in the management of ophthalmic tumours. He has a large body of peer-reviewed publications and book chapters in the field of ocular oncology. He has been an invited guest speaker and chair moderator at several international conferences. Dr. Krema has been invited to give courses and teaching sessions in ocular oncology to residents and fellows in several countries; he was granted “The Residents’ Award for the Best Teacher in the Department of Ophthalmology of University of Toronto” in 2013, and has been titled an Honorary Fellow of the International Council of Ophthalmology in 2017. He has been an ad hoc peer reviewer to a number of high-ranked Ophthalmology journals, and he has been the ocular oncology section editor of a number of ophthalmology journals.

References

Chien JL, Sioufi K, Surakiatchanukul T, et al. Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes. Curr Opin Ophthalmol. 2017 May;28(3):228-37. DOI: https://doi.org/10.1097/ICU.0000000000000361

Shields CL, Kels JG, Shields JA. Melanoma of the eye: revealing hidden secrets, one at a time. Clin Dermatol. 2015 Mar-Apr;33(2):183-96. DOI: https://doi.org/10.1016/j.clindermatol.2014.10.010

Kaliki S, Shields CL. Uveal melanoma: relatively rare but deadly cancer. Eye (Lond). 2017 Feb;31(2):241-57. DOI: https://doi.org/10.1038/eye.2016.275

Kaur G, Anthony SA. Multimodal imaging of suspicious choroidal neoplasms in a primary eye-care clinic. Clin Exp Optom. 2017 Nov;100(6):549-62 DOI: https://doi.org/10.1111/cxo.12537

Dalvin LA, Shields CL, Ancona-Lezama DA, et al. Combination of multimodal imaging features predictive of choroidal nevus transformation into melanoma. Br J Ophthalmol. 2019 Oct;103(10):1441-7. DOI: https://doi.org/10.1136/bjophthalmol-2018-312967

Bonnet LA, Conway RM, Lim LA. Congenital hypertrophy of the retinal pigment epithelium (CHRPE) as a screening marker for familial adenomatous polyposis (FAP). Systematic literature review and screening recommendations. Clin Ophthalmol. 2022 Mar 15;16:765-74. DOI: https://doi.org/10.2147/OPTH.S354761

Shields JA, Demirci H, Mashayekhi A, et al. Melanocytoma of the optic disk: A review. Indian J Ophthalmol. 2019 Dec;67(12):1949-58. DOI: https://doi.org/10.4103/ijo.IJO_2039_19

Font RL, Moura RA, Shetlar DJ, et al. Combined hamartoma of sensory retina and retinal pigment epithelium. Retina. 1989;9(4):302-11. DOI: https://doi.org/10.1097/00006982-198909040-00011

Shields JA, Shields CL. Tumors and related lesions of the pigmented epithelium. Asia Pac J Ophthalmol (Phila). 2017 Mar-Apr;6(2):215-23.

Shields CL, Kalafatis NE, Gad M, et al. Metastatic tumours to the eye. Review of metastasis to the iris, ciliary body, choroid, retina, optic disc, vitreous, and/or lens capsule. Eye (Lond). 2023 Apr;37(5):809-14. DOI: https://doi.org/10.1038/s41433-022-02015-4

White VA. Understanding and classification of ocular lymphomas. Ocul Oncol Pathol. 2019 Oct;5(6):379-86. DOI: https://doi.org/10.1159/000499845

Hage DG, Wahab CH, Kheir WJ. Choroidal sarcoid granuloma: a case report and review of the literature. J Ophthalmic Inflamm Infect. 2022 Sep 29;12(1):31. DOI: https://doi.org/10.1186/s12348-022-00309-y

Lupidi M, Centini C, Castellucci G, et al. New insights on circumscribed choroidal hemangioma: “bench to bedside”. Graefes Arch Clin Exp Ophthalmol. 2024 Apr;262(4):1093-1110. DOI: https://doi.org/10.1007/s00417-023-06179-x

Ciancimino C, Di Pippo M, Rullo D, et al. An update on multimodal ophthalmological imaging of diffuse choroidal hemangioma in Sturge-Weber syndrome. Vision (Basel). 2023 Oct 6;7(4):64. DOI: https://doi.org/10.3390/vision7040064

de Paula A, Abdolrahimzadeh S, Fragiotta S, et al. Current concepts on ocular vascular abnormalities in the phakomatoses. Semin Ophthalmol. 2021 Oct 3;36(7):549-60. DOI: https://doi.org/10.1080/08820538.2021.1900284

Ebrahimiadib N, Maleki A, Fadakar K, et al. Vascular abnormalities in uveitis. Surv Ophthalmol. 2021 Jul-Aug;66(4):653-67. DOI: https://doi.org/10.1016/j.survophthal.2020.12.006

Alameddine RM, Mansour AM, Kahtani E. Review of choroidal osteomas. Middle East Afr J Ophthalmol. 2014 Jul-Sep;21(3):244-50. DOI: https://doi.org/10.4103/0974-9233.134686

Shields JA, Shields CL. CME review: sclerochoroidal calcification: the 2001 Harold Gifford Lecture. Retina. 2002 Jun;22(3):251-61. DOI: https://doi.org/10.1097/00006982-200206000-00001

Hodgson N, Kinori M, Goldbaum MH, et al. Ophthalmic manifestations of tuberous sclerosis: a review. Clin Exp Ophthalmol. 2017 Jan;45(1):81-6. DOI: https://doi.org/10.1111/ceo.12806

Zhou M, Tang J, Fan J, et al. Recent progress in retinoblastoma: Pathogenesis, presentation, diagnosis and management. Asia Pac J Ophthalmol (Phila). 2024 Mar-Apr;13(2):100058. DOI: https://doi.org/10.1016/j.apjo.2024.100058

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Published

2024-08-30

How to Cite

1.
Krema H. Ocular Fundus Tumours: A Simplified Clinical Classification. Can Eye Care Today [Internet]. 2024 Aug. 30 [cited 2024 Nov. 16];3(3):25–32. Available from: https://canadianeyecaretoday.com/article/view/3-3-krema

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