Corneal Lumps and Bumps

Authors

  • Mohammad Al-Fayyadh, MD Department of Ophthalmology, Faculty of Medicine, University of Ottawa, Ottawa, ON
  • Mona Koaik, MD Department of Ophthalmology, Faculty of Medicine, University of Ottawa, Ottawa, ON

Abstract

Patients present to the ophthalmologist with various corneal pathologies, and it is imperative to differentiate the benign from the malignant at the slit lamp to provide them proper guidance and treatment. These conditions tend to play a more significant role in the pre-operative cataract evaluation as they typically affect post-operative visual rehabilitation. In this review, we aim to examine the differentiating factors of the many lumps and bumps that affect the cornea and the available ways for surgeons to treat them in Canada. 

Author Biographies

Mohammad Al-Fayyadh, MD, Department of Ophthalmology, Faculty of Medicine, University of Ottawa, Ottawa, ON

Dr. Mohammad Al-Fayyadh is a board certified ophthalmologist who graduated from medical school with a bachelor’s degree in medicine and surgery (Aljouf University, Saudi Arabia). He completed his ophthalmology residency in Saudi Arabia and is currently a Cornea, Anterior segment and Refractive Surgery Fellow at the University of Ottawa.

Mona Koaik, MD, Department of Ophthalmology, Faculty of Medicine, University of Ottawa, Ottawa, ON

Dr. Mona Koaik is a Cornea, Anterior Segment and Refractive Surgeon at the University of Ottawa Eye Institute where she also serves as an Assistant Professor of Ophthalmology. She received her Bachelor and Medical degrees from the American University of Beirut where she also did her Ophthalmology training. She then completed her fellowship in Cornea and Anterior Segment Surgery in Ottawa. She has an enthusiastic and keen interest in cataract surgery, refractive cataract and cornea surgeries, and ocular surface surgery. Dr. Koaik has a very keen interest in research and innovations in Ophthalmology and has published several articles and presented at various national and international meetings. Lately, her focus has shifted to more anterior segment and corneal diseases, and she is currently involved in starting and conducting many projects related to medical and surgical treatment of corneal diseases, as well as projects related to corneal and lenticular refractive surgery.

References

Rezvan F, Khabazkhoob M, Hooshmand E et al. Prevalence and risk factors of pterygium: a systematic review and meta-analysis. Surv Ophthalmol [Internet]. 2018 Sep 1 [cited 2024 Jan 3];63(5):719-35. Available from: http://www.surveyophthalmol.com/article/S0039625717302655/fulltext

Linaburg T, Choi D, Bunya VY et al. Systematic Review: Effects of pterygium and pingueculum on the ocular surface and efficacy of surgical excision. Cornea. 2021 Feb 1;40(2):258-267.

Shahraki T, Arabi A, Feizi S. Pterygium: an update on pathophysiology, clinical features, and management. Vol. 13, Therapeutic Advances in Ophthalmology. SAGE Publications Ltd; 2021.

Levinger E, Sorkin N, Sella S et al. Posterior corneal surface changes after pterygium excision surgery [Internet]. 2020. Available from: www.corneajrnl.com

Bahar I, Loya N, Weinberger D, et al. Effect of pterygium surgery on corneal topography: A prospective study. Cornea. 2004 Mar;23(2):113-117.

Patel ED, Rhee MK. Surgical Techniques and Adjuvants for the Management of Pterygium. Vol. 48, Eye and Contact Lens. Lippincott Williams and Wilkins; 2022. p. 3–13.

Janson BJ, Sikder S. Surgical Management of Pterygium [Internet]. 2014. Available from: www.theocularsurface.com

Sabater-Cruz N DBMRJ et al. Postoperative treatment compliance rate and complications with two different protocols after pterygium excision and conjunctival autografting. Eur J Ophthalmol. 2021 May;31(3):932-937.

Taher NO, Alnabihi AN, Hersi RM et al. Amniotic membrane transplantation and conjunctival autograft combined with mitomycin C for the management of primary pterygium: A systematic review and meta-analysis. Front Med 2002;9.

Ghiasian L, Samavat B, Hadi Y et al. Recurrent pterygium: A review. J Curr Ophthalmol. 2022 Jan 6;33(4):367-378.

Kozma K, Dömötör ZR, Csutak A et al. Topical pharmacotherapy for ocular surface squamous neoplasia: systematic review and meta-analysis. Sci Rep. 2022 Dec 1;12(1).

Gichuhi S, Ohnuma S ichi, Sagoo MS et al. Pathophysiology of ocular surface squamous neoplasia. Vol. 129, Experimental Eye Research. Academic Press; 2014. p. 172–82.

Lloyd HWCM, Arunga S, Twinamasiko A et al. Predictors of Ocular Surface Squamous Neoplasia and Conjunctival Squamous Cell Carcinoma among Ugandan Patients: A Hospital-based Study. 2019; Available from: www.meajo.org

Wylegala A, Sripawadkul W, Zein M et al. Topical 1% 5-fluorouracil eye drops as primary treatment for ocular surface squamous neoplasia: Long-term follow-up study. Ocul Surf. 2023;27:67-74.

Kieval JZ, Karp CL, Shousha MA, Galor A et al. Ultra-high resolution optical coherence tomography for differentiation of ocular surface squamous neoplasia and pterygia. Ophthalmology. 2012;119(3):481-486.

Monroy D, Serrano A, Galor A, Karp CL. Medical treatment for ocular surface squamous neoplasia. Eye. 2023;37(5):885-893.

Yeoh CHY, Lee JJR, Lim BXH et al. The management of ocular surface squamous neoplasia (OSSN). International Journal of Molecular Sciences. MDPI; 2023.

Urbinati F, Borroni D, Rodríguez-Calvo-de-Mora M et al. Pseudopterygium: An algorithm approach based on the current evidence. Diagnostics. 2022 July 30;12(8):1843.

Ravichandran S, Natarajan R, Janarthanam J. Pterygium versus pseudo-pterygium in black and white. Indian J Ophthalmol. 2023;3(4):1206.

Farjo AA, Halperin GI, Syed N, et al. Salzmann’s nodular corneal degeneration clinical characteristics and surgical outcomes. Cornea. 2006 Jan;25(1):11-15.

Maharana PK, Sharma N, Das S, Agarwal T et al. Salzmann’s Nodular Degeneration [Internet]. 2016. Available from: www.theocularsurface.com

Paranjpe V, Galor A, Monsalve P, et al. Salzmann nodular degeneration: Prevalence, impact, and management strategies. Vol. 13, Clinical Ophthalmology. Dove Medical Press Ltd; 2019. p. 1305-1314.

Raber IM, Eagle RC. Peripheral Hypertrophic Subepithelial Corneal Degeneration [Internet]. 2021. Available from: www.corneajrnl.com

Järventausta PJ, Tervo TMT, Kivelä T et al. Peripheral hypertrophic subepithelial corneal degeneration – clinical and histopathological features. Acta Ophthalmologica (Oxford, England). 2014;92(8):774-782.

Hamada S, Darrad K, McDonnell PJ. Salzmann’s nodular corneal degeneration (SNCD): Clinical findings, risk factors, prognosis and the role of previous contact lens wear. Contact Lens and Anterior Eye. 2011 Aug;34(4):173-178.

Das S, Langenbucher A, Pogorelov P et al. Long-term outcome of excimer laser phototherapeutic keratectomy for treatment of Salzmann’s nodular degeneration. J Cataract Refract Surg. 2005;31(7):1386-1391.

Bowers PJ, Price MO, Zeldes SS et al. Superficial keratectomy with mitomycin-C for the treatment of Salzmann’s nodules. J Cataract Refract Surg. 2003 Jul 1;29(7):1302-1306.

Reddy JC, Rapuano CJ, Felipe AF et al. Quality of vision after excimer laser phototherapeutic keratectomy with intraoperative mitomycin-c for Salzmann nodular degeneration. Eye Contact Lens. 2014;40(4):213-219.

Goerlitz-Jessen MF, Gupta PK, Kim T. Impact of epithelial basement membrane dystrophy and Salzmann nodular degeneration on biometry measurements. J Cataract Refract Surg. 2019 Aug 1;45(8):1119-1123.

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Published

2024-02-28

How to Cite

1.
Al-Fayyadh M, Koaik M. Corneal Lumps and Bumps. Can Eye Care Today [Internet]. 2024 Feb. 28 [cited 2024 Nov. 21];3(1):18–26. Available from: https://canadianeyecaretoday.com/article/view/3-1-al-fayyadh_et_al

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