Management of recurrent corneal erosions: A stepwise approach

Authors

  • Yelin Yang, MD, FRCSC Michael Garron (Toronto East General) Hospital

DOI:

https://doi.org/10.58931/cect.2023.2225

Abstract

Recurrent corneal erosions syndrome (RCES) is a common disorder characterized by recurring episodes of corneal epithelial breakdown. Symptoms include pain, tearing or redness typically worse upon awakening or overnight during rapid eye movements (REM) sleep. Severe episodes can last for days, leading to epithelial defects and corneal scarring. Recurrences can be frequent and debilitating for patients. The aim of this review is to summarize the current medical and surgical methods available to treat RCES.

Author Biography

Yelin Yang, MD, FRCSC, Michael Garron (Toronto East General) Hospital

Dr. Yelin Yang received her Bachelor of Health Sciences from McMaster University followed by her Doctor of Medicine from the University of Ottawa. She completed her ophthalmology residency at the University of Toronto and her fellowship in Cornea and External Diseases at the University of Montreal. She is currently practicing at Toronto East General Hospital.

References

Miller DD, Hasan SA, Simmons NL, Stewart MW. Recurrent corneal erosion: a comprehensive review. Clinical Ophthalmology (Auckland, NZ). 2019;13:325. DOI: https://doi.org/10.2147/OPTH.S157430

Reidy JJ, Paulus MP, Gona S. Recurrent erosions of the cornea: epidemiology and treatment. Cornea. 2000 Nov 1;19(6):767-71. DOI: https://doi.org/10.1097/00003226-200011000-00001

Ramamurthi S, Rahman MQ, Dutton GN, Ramaesh K. Pathogenesis, clinical features and management of recurrent corneal erosions. Eye. 2006 Jun;20(6):635-44.

Dursun D, Kim MC, Solomon A, Pflugfelder SC. Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. American journal of Ophthalmology. 2001 Jul 1;132(1):8-13. DOI: https://doi.org/10.1016/S0002-9394(01)00913-8

Wang L, Tsang H, Coroneo M. Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. Clinical & Experimental Ophthalmology. 2008 Jan;36(1):8-12. DOI: https://doi.org/10.1111/j.1442-9071.2007.01648.x

Ziakas NG, Boboridis KG, Terzidou C, Naoumidi TL, Mikropoulos D, Georgiadou EN, Georgiadis NS. Long-term follow up of autologous serum treatment for recurrent corneal erosions. Clinical & Experimental Ophthalmology. 2010 Oct;38(7):683-7. DOI: https://doi.org/10.1111/j.1442-9071.2010.02304.x

del Castillo JM, de la Casa JM, Sardiña RC, Fernández RM, Feijoo JG, Gómez AC, Rodero MM, Sánchez JG. Treatment of recurrent corneal erosions using autologous serum. Cornea. 2002 Nov 1;21(8):781-3. DOI: https://doi.org/10.1097/00003226-200211000-00010

Napoli PE, Braghiroli M, Iovino C, Demarinis G, Fossarello M. A study of refractory cases of persistent epithelial defects associated with dry eye syndrome and recurrent corneal erosions successfully treated with cyclosporine A 0.05% eye drops. Drug Design, Development and Therapy. 2019 Jun 19:2001-8. DOI: https://doi.org/10.2147/DDDT.S207453

Fraunfelder FW, Cabezas M. Treatment of recurrent corneal erosion by extended-wear bandage contact lens. Cornea. 2011 Feb 1;30(2):164-6. DOI: https://doi.org/10.1097/ICO.0b013e3181e84689

Ahad MA, Anandan M, Tah V, Dhingra S, Leyland M. Randomized controlled study of ocular lubrication versus bandage contact lens in the primary treatment of recurrent corneal erosion syndrome. Cornea. 2013 Oct 1;32(10):1311-4. DOI: https://doi.org/10.1097/ICO.0b013e31829dec39

Zauberman NA, Artornsombudh P, Elbaz U, Goldich Y, Rootman DS, Chan CC. Anterior stromal puncture for the treatment of recurrent corneal erosion syndrome: patient clinical features and outcomes. American Journal of Ophthalmology. 2014 Feb 1;157(2):273-9. DOI: https://doi.org/10.1016/j.ajo.2013.10.005

Yang Y, Mimouni M, Trinh T, Sorkin N, Cohen E, Santaella G, Rootman DS, Chan CC, Slomovic AR. Phototherapeutic keratectomy versus epithelial debridement combined with anterior stromal puncture or diamond burr for recurrent corneal erosions. Canadian Journal of Ophthalmology. 2022 Feb 22. DOI: https://doi.org/10.1016/j.jcjo.2022.01.023

Ramamurthi S, Rahman MQ, Dutton GN, Ramaesh K. Pathogenesis, clinical features and management of recurrent corneal erosions. Eye. 2006 Jun;20(6):635-44. DOI: https://doi.org/10.1038/sj.eye.6702005

Bae SS, Chan CC. Superficial keratectomy: indications and outcomes. Canadian Journal of Ophthalmology. 2018 Dec 1;53(6):553-9. DOI: https://doi.org/10.1016/j.jcjo.2018.01.030

Wong VW, Chi SC, Lam DS. Diamond burr polishing for recurrent corneal erosions: results from a prospective randomized controlled trial. Cornea. 2009 Feb 1;28(2):152-6. DOI: https://doi.org/10.1097/ICO.0b013e31818526ec

Soong HK, Farjo Q, Meyer RF, Sugar A. Diamond burr superficial keratectomy for recurrent corneal erosions. British Journal of Ophthalmology. 2002 Mar 1;86(3):296-8. DOI: https://doi.org/10.1136/bjo.86.3.296

Dua HS, Lagnado R, Raj D, Singh R, Mantry S, Gray T, Lowe J. Alcohol delamination of the corneal epithelium: an alternative in the management of recurrent corneal erosions. Ophthalmology. 2006 Mar 1;113(3):404-11. DOI: https://doi.org/10.1016/j.ophtha.2005.10.049

Mhéalóid ÁN, Lukasik T, Power W, Murphy CC. Alcohol delamination of the corneal epithelium for recurrent corneal erosion syndrome. International Journal of Ophthalmology. 2018;11(7):1129.

Oh JY, Yu JM, Ko JH. Analysis of ethanol effects on corneal epithelium. Investigative Ophthalmology & Visual Science. 2013 Jun 1;54(6):3852-6. DOI: https://doi.org/10.1167/iovs.13-11717

Maini R, Loughnan MS. Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome. British Journal of Ophthalmology. 2002 Mar 1;86(3):270-2. DOI: https://doi.org/10.1136/bjo.86.3.270

Cavanaugh TB, Lind DM, Cutarelli PE, Mack RJ, Durrie DS, Hassanein KM, Graham CE. Phototherapeutic keratectomy for recurrent erosion syndrome in anterior basement membrane dystrophy. Ophthalmology. 1999 May 1;106(5):971-6. DOI: https://doi.org/10.1016/S0161-6420(99)00540-0

Baryla J, Pan YI, Hodge WG. Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. Cornea. 2006 Dec 1;25(10):1150-2. DOI: https://doi.org/10.1097/01.ico.0000240093.65637.90

Downloads

Published

2023-05-17

How to Cite

1.
Yang Y. Management of recurrent corneal erosions: A stepwise approach. Can Eye Care Today [Internet]. 2023 May 17 [cited 2024 Nov. 23];2(2):4–8. Available from: https://canadianeyecaretoday.com/article/view/2-2-yang

Issue

Section

Articles