Uveitis following COVID-19 vaccination
A literature review for Canadian ophthalmologists
DOI:
https://doi.org/10.58931/cect.2022.1213Abstract
The advent of SARS-CoV-2 (COVID-19) vaccines markedly reduced adverse outcomes associated with COVID-19 infection. With over 12 billion doses of COVID-19 vaccines administered globally as of June 2022, reports have emerged of ocular sequelae following immunization. Vaccination remains the most effective way to reduce the risk of COVID-19-related morbidity and mortality. However, it is important for ophthalmologists to understand the potential adverse events related to SARS-CoV-2 vaccination to provide opportunity for appropriate patient counselling and diagnosis. This review outlines the reported associations between COVID-19 vaccination and uveitis, including proposed mechanisms and recommendations for treating ophthalmologists.
References
Haseeb AA, Solyman O, Abushanab MM, Abo Obaia AS, Elhusseiny AM. Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective. Vaccines. 2022;10(2):342. doi:10.3390/vaccines10020342 DOI: https://doi.org/10.3390/vaccines10020342
Bettini E, Locci M. SARS-CoV-2 mRNA Vaccines: Immunological Mechanism and Beyond. Vaccines. 2021;9(2):147. doi:10.3390/vaccines9020147 DOI: https://doi.org/10.3390/vaccines9020147
Teijaro JR, Farber DL. COVID-19 vaccines: modes of immune activation and future challenges. Nat Rev Immunol. 2021;21(4):195-197. doi:10.1038/s41577-021-00526-x DOI: https://doi.org/10.1038/s41577-021-00526-x
Tomkins-Netzer O, Sar S, Barnett-Griness O, Friedman B, Shyriaieva H, Saliba W. Association between vaccination with the BNT162b2 mRNA COVID-19 vaccine and non-infectious uveitis: a population-based study. Ophthalmology. Published online May 2022:S0161642022003955. doi:10.1016/j.ophtha.2022.05.015 DOI: https://doi.org/10.1016/j.ophtha.2022.05.015
Rabinovitch T, Ben-Arie-Weintrob Y, Hareuveni-Blum T, et al. Uveitis After The BNT162b2 mRNA Vaccination Against SARS-CoV-2 Infection: A Possible Association. Retina. 2021;41(12):2462-2471. doi:10.1097/IAE.0000000000003277 DOI: https://doi.org/10.1097/IAE.0000000000003277
Ferrand N, Accorinti M, Agarwal M, et al. COVID-19 Vaccination and Uveitis: Epidemiology, Clinical Features and Visual Prognosis. Ocular Immunology and Inflammation. Published online April 11, 2022:1-9. doi:10.1080/09273948.2022.2058964 DOI: https://doi.org/10.1080/09273948.2022.2058964
Bolletta E, Iannetta D, Mastrofilippo V, et al. Uveitis and Other Ocular Complications Following COVID-19 Vaccination. JCM. 2021;10(24):5960. doi:10.3390/jcm10245960 DOI: https://doi.org/10.3390/jcm10245960
Sangoram R, Mahendradas P, Bhakti Mishra S, Kawali A, Sanjay S, Shetty R. Herpes Simplex Virus 1 Anterior Uveitis following Coronavirus Disease 2019 (COVID-19) Vaccination in an Asian Indian Female. Ocular Immunology and Inflammation. Published online April 11, 2022:1-5. doi:10.1080/09273948.2022.2055580 DOI: https://doi.org/10.1080/09273948.2022.2055580
Hwang JH. Uveitis after COVID-19 Vaccination. Case Rep Ophthalmol. 2022;13(1):124-127. doi:10.1159/000521785 DOI: https://doi.org/10.1159/000521785
Mudie LI, Zick JD, Dacey MS, Palestine AG. Panuveitis following Vaccination for COVID-19. Ocular Immunology and Inflammation. 2021;29(4):741-742. doi:10.1080/09273948.2021.1949478 DOI: https://doi.org/10.1080/09273948.2021.1949478
Saraceno JJF, Souza GM, dos Santos Finamor LP, Nascimento HM, Belfort R. Vogt-Koyanagi-Harada Syndrome following COVID-19 and ChAdOx1 nCoV-19 (AZD1222) vaccine. Int J Retin Vitr. 2021;7(1):49. doi:10.1186/s40942-021-00319-3 DOI: https://doi.org/10.1186/s40942-021-00319-3
Ding X, Chang Q. Probable Vogt–Koyanagi–Harada Disease after COVID-19 Vaccination: Case Report and Literature Review. Vaccines. 2022;10(5):783. doi:10.3390/vaccines10050783 DOI: https://doi.org/10.3390/vaccines10050783
Accorinti M, Saturno MC, Manni P. Vogt-Koyanagi-Harada Relapse after COVID-19 Vaccination. Ocular Immunology and Inflammation. Published online February 24, 2022:1-6. doi:10.1080/09273948.2022.2027469 DOI: https://doi.org/10.1080/09273948.2022.2027469
Brunet de Courssou JB, Tisseyre M, Hadjadj J, et al. De Novo Vogt-Koyanagi-Harada Disease following Covid-19 Vaccine: A Case Report and Literature Overview. Ocular Immunology and Inflammation. Published online February 3, 2022:1-4. doi:10.1080/09273948.2022.2028291 DOI: https://doi.org/10.1080/09273948.2022.2028291
Jakirlic N, Harris T. Case Report: Acute Posterior Multifocal Placoid Pigment Epitheliopathy after SARS-CoV-2 Vaccination. Optom Vis Sci. 2022;99(6):534-539. doi:10.1097/OPX.0000000000001900 DOI: https://doi.org/10.1097/OPX.0000000000001900
Smith E, Tran T, Gillies A, Yeung S, Ma PE. Multiple Evanescent White Dot Syndrome following COVID-19 mRNA Vaccination in Two Patients. Ocular Immunology and Inflammation. Published online February 24, 2022:1-4. doi:10.1080/09273948.2022.2032198 DOI: https://doi.org/10.1080/09273948.2022.2032198
Inagawa S, Onda M, Miyase T, et al. Multiple evanescent white dot syndrome following vaccination for COVID-19: A case report. Medicine. 2022;101(2):e28582. doi:10.1097/MD.0000000000028582 DOI: https://doi.org/10.1097/MD.0000000000028582
Xu Y, Shen W. Presumed Recurrent MEWDS following Covid-19 Vaccination. Ocular Immunology and Inflammation. 2021;29(6):1234-1237. doi:10.1080/09273948.2021.1985524 DOI: https://doi.org/10.1080/09273948.2021.1985524
Tomishige KS, Novais EA, Finamor LP dos S, Nascimento HM do, Belfort Jr. R. Multiple evanescent white dot syndrome (MEWDS) following inactivated COVID-19 vaccination (Sinovac-CoronaVac). ABO. 2022;85(2). doi:10.5935/0004-2749.20220070 DOI: https://doi.org/10.5935/0004-2749.20220016
Lin KS, Hsieh MH. Multiple Evanescent White Dot Syndrome Following Medigen Vaccine Biologics Corporation COVID-19 Vaccination. Ocular Immunology and Inflammation. Published online April 20, 2022:1-4. doi:10.1080/09273948.2022.2062388 DOI: https://doi.org/10.1080/09273948.2022.2062388
Mishra SB, Mahendradas P, Kawali A, Sanjay S, Shetty R. Reactivation of varicella zoster infection presenting as acute retinal necrosis post COVID 19 vaccination in an Asian Indian male. European Journal of Ophthalmology. Published online September 18, 2021:112067212110464. doi:10.1177/11206721211046485 DOI: https://doi.org/10.1177/11206721211046485
Cunningham ET, Moorthy RS, Fraunfelder FW, Zierhut M. Vaccine-Associated Uveitis. Ocular Immunology and Inflammation. 2019;27(4):517-520. doi:10.1080/09273948.2019.1626188 DOI: https://doi.org/10.1080/09273948.2019.1626188
Benage M, Fraunfelder FW. Vaccine-Associated Uveitis. Mo Med. 2016;113(1):48-52.
Maleki A, Look-Why S, Manhapra A, Foster CS. COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence? J Ophthalmic Vis Res. 2021;16(3):490-501. doi:10.18502/jovr.v16i3.9443 DOI: https://doi.org/10.18502/jovr.v16i3.9443
Fantini MC, Pallone F, Monteleone G. Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies. World J Gastroenterol. 2009;15(20):2472-2478. doi:10.3748/wjg.15.2472 DOI: https://doi.org/10.3748/wjg.15.2472
Català A, Muñoz-Santos C, Galván-Casas C, et al. Cutaneous reactions after SARS-CoV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases*. Br J Dermatol. 2022;186(1):142-152. doi:10.1111/bjd.20639 DOI: https://doi.org/10.1111/bjd.20639
Katsikas Triantafyllidis K, Giannos P, Mian IT, Kyrtsonis G, Kechagias KS. Varicella Zoster Virus Reactivation Following COVID-19 Vaccination: A Systematic Review of Case Reports. Vaccines. 2021;9(9):1013. doi:10.3390/vaccines9091013 DOI: https://doi.org/10.3390/vaccines9091013
Sun Y, Miller DC, Akpandak I, Chen EM, Arnold BF, Acharya NR. Association between immunosuppressive drugs and COVID-19 outcomes in patients with non-infectious uveitis in a large US claims database. Ophthalmology. Published online May 2022:S0161642022003621. doi:10.1016/j.ophtha.2022.05.008 DOI: https://doi.org/10.1016/j.ophtha.2022.05.008
Vu AF, Kodati S, Lin P, Bodaghi B, Emami-Naeini P. Impact of the COVID-19 pandemic on uveitis patient care. Br J Ophthalmol. Published online January 24, 2022:bjophthalmol-2021-320368. doi:10.1136/bjophthalmol-2021-320368 DOI: https://doi.org/10.1136/bjophthalmol-2021-320368
Vaccine Adverse Event Reporting System (VAERS), https://vaers.hhs.gov/. Accessed 1 Jul. 2022.
Uppsala Monitoring System (UMC), https://www.who-umc.org/. Accessed 1 Jul. 2022
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Canadian Eye Care Today
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.